Thio-NADP

• UNSPSC Description:

  Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca2+ release[1].

• Target Antigen:

  Calcium Channel

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/thio-nadp.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H]([N+]5=CC=CC(C(N)=S)=C5)[C@@H]([C@@H]4O)O)([O-])=O)(O)=O

• Molecular Weight:

  759.47

• References & Citations:

  [1]Bizouarn T, et al. The involvement of NADP(H) binding and release in energy transduction by proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli. Biochim Biophys Acta. 1995 Apr 4;1229(1):49-58.|[2]Dickey D M, et al. Thio-NADP is not an antagonist of NAADP[J]. Cell biochemistry and biophysics, 1998, 28: 63-73.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  19254-05-8