Thio-acridone

• Description :

  Thio-acridone (SACD) is a photosensitizer (HAF-PSs) . Thio-acridone forms a long-lived triplet state upon excitation by 470 nm visible light, , ultimately generating singlet oxygen to damage the structures and functions of target cells such as cancer cells. Thio-acridone is promising for research of cancers[1]. Thio-acridone is a CDK4/Cyclin D1 inhibitor (IC50 = 2 uM) [2].

• CAS Number :

  [6540-78-9]

• Product Name Alternative :

  SACD

• UNSPSC :

  12352005

• Target :

  CDK

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  S=C1C2=C(NC3=C1C=CC=C3)C=CC=C2

• Molecular Formula :

  C13H9NS

• Molecular Weight :

  211.28

• References & Citations :

  [1]Acquah C, et al. Electronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible light. Phys Chem Chem Phys. 2024 Nov 27;26 (46) :28980-28991.|[2]Kubo A, Nakagawa K, Varma RK, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999;5 (12) :4279-4286.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK4