NADP

• Description :

  NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].

• Product Name Alternative :

  DDD00107587

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/NADP.html

• Purity :

  99.70

• Solubility :

  H2O : 125 mg/mL (ultrasonic)

• Smiles :

  O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O1)([O-])OP(OC[C@H]3O[C@@H](N4C5=NC=NC(N)=C5N=C4)[C@H](OP(O)(O)=O)[C@@H]3O)(O)=O

• Molecular Formula :

  C21H28N7O17P3

• Molecular Weight :

  743.41

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125.|[2]Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34 (9) :12565-12576. |[3]Ilter D, et al. NADK-mediated de novo NADP (H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. |[4]Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29 (2) :203-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• Citation 01 :

  Cell Oncol (Dordr) . 2023 Jun;46 (3) :761-776.|Insect Biochem Mol Biol. 2023 Jun:157:103958.|World J Microbiol Biotechnol. 2024 Oct 19;40 (11) :357.|Cell Prolif. 2021 Apr;54 (4) :e13015.|Eur J Pharm Sci. 2023 Aug 1:187:106475.|FASEB J. 2024 Jul 31;38 (14) :e23844.

• CAS Number :

  [53-59-8]