Thio-TEPA

• Description :

  Thio-TEPA is a DNA alkylating agent, with antitumor activity.

• UNSPSC :

  12352005

• Hazard Statement :

  H300, H350

• Target :

  Antibiotic; Bacterial; DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/Thio-TEPA.html

• Purity :

  99.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  S=P(N1CC1)(N2CC2)N3CC3

• Molecular Formula :

  C6H12N3PS

• Molecular Weight :

  189.22

• Precautions :

  H300, H350

• References & Citations :

  [1]Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28 (6) :441-7.|[2]Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21 (4) :327-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [52-24-4]