Thio-ITP

Thio-ITP

• CAS Number: 27652-34-2
• UNSPSC Description: Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thio-itp.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(O)(O)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=CN3)=S)N=C2
• Molecular Weight: 524.23
• References & Citations: [1]Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported