Thio-ITP

• Description:

  Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM) [1].

• Product Name Alternative:

  6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thio-itp.html

• Solubility:

  10 mM in DMSO

• Smiles:

  SC1=NC=NC2=C1N=CN2[C@H]3[C@H] (O) [C@H] (O) [C@@H] (COP (OP (OP (O) (O) =O) (O) =O) (O) =O) O3

• Molecular Formula:

  C10H15N4O13P3S

• Molecular Weight:

  524.23

• References & Citations:

  [1]Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43 (8) :3655-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  27652-34-2