PPARγ agonist 8

• Description:

  PPARγ agonist 8 is an agonist of PPARγ. PPARγ agonist 8 induces peroxisome proliferator response element (PPRE) -luciferase activity with an EC50 of 0.2 μM[1].

• UNSPSC:

  12352005

• Target:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pparγ-agonist-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC (CC1=C/C (C2=CC=C (F) C=C21) =C\C3=CC=C (C=C3) SC (F) (F) F) =O

• Molecular Formula:

  C19H12F4O2S

• Molecular Weight:

  380.36

• References & Citations:

  [1]Felts AS, et.al. Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. J Med Chem. 2008 Aug 28;51 (16) :4911-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PPARγ

• CAS Number:

  1049800-41-0