PROTAC KRAS G12C degrader-2

PROTAC KRAS G12C degrader-2

• CAS Number: 2378257-72-6
• UNSPSC Description: PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS[1].
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-kras-g12c-degrader-2.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)CN5CCN(CC5)CC6CCN(C7=CC=C(C(N(C8C(NC(CC8)=O)=O)C9=O)=O)C9=C7)CC6)N=C4N%10CCN(CC%10)C(C=C)=O
• Molecular Weight: 958.47
• References & Citations: [1]Crew Andrew, et al. Preparation of bifunctional compounds as modulators of proteolysis useful for treating cancer. World Intellectual Property Organization, WO2019195609 A2. 2019-10-10.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported