KRAS G12C degrader-1
CAT:
804-HY-153881
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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KRAS G12C degrader-1
- CAS Number: 2768099-51-8
- UNSPSC Description: KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: [1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-kras-g12c-degrader-3.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
- Molecular Weight: 1159.81
- References & Citations: [1]Methods and compositions for targeted protein degradation.WO2022078414.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported