PROTAC KRAS G12D degrader 2

PROTAC KRAS G12D degrader 2

• UNSPSC Description: PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker[1].
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/protac-kras-g12d-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7
• Molecular Weight: 884.99
• References & Citations: [1]Grifagni D, et al. Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2. ACS Medicinal Chemistry Letters, 2024.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported