PROTAC KRAS G12D degrader 2

• UNSPSC Description:

  PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker[1].

• Target Antigen:

  PROTACs; Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/protac-kras-g12d-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7

• Molecular Weight:

  884.99

• References & Citations:

  [1]Grifagni D, et al. Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2. ACS Medicinal Chemistry Letters, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported