pan-KRAS degrader 1

pan-KRAS degrader 1

• CAS Number: 2937327-83-6
• UNSPSC Description: pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant Ki value of 25 nM for KRASG12V .pan-KRAS degrader 1 has antitumor activity[1].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pan-kras-degrader-1.html
• Smiles: NC(S1)=C(C#N)C2=C1CCC[C@@]2(C3=NC(C4=NC(N5[C@@H](C)CNCCC5)=NC=C4)=NO3)C
• Molecular Weight: 450.56
• References & Citations: [1]Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385(6715):1338-1347.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported