PF-04523655

• Description:

  PF-04523655 is a siRNA directed against RTP801 gene. RTP801 is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

• UNSPSC:

  12352208

• Target:

  Small Interfering RNA (siRNA)

• Type:

  Oligonucleotides

• Related Pathways:

  Epigenetics

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-04523655.html

• Solubility:

  10 mM in H2O

• Smiles:

  [PF-04523655]

• References & Citations:

  [1]Rittenhouse KD, Johnson TR, Vicini P, et al. RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801. Invest Ophthalmol Vis Sci. 2014;55 (3) :1232-1240.|[2]Nguyen QD, Schachar RA, Nduaka CI, et al. Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study) . Ophthalmology. 2012;119 (9) :1867-1873.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2

• CAS Number:

  1420046-64-5