ISIS 5132

• Description:

  ISIS 5132 is a 20-base phosphorothioate oligonucleotide that specifically down-regulates c-raf expression.

• Product Name Alternative:

  CGP 69846A; ISIS 9271

• UNSPSC:

  12352208

• Target:

  Raf

• Type:

  Oligonucleotides

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/isis-5132.html

• Solubility:

  10 mM in H2O

• Smiles:

  [ISIS5132]

• References & Citations:

  [1]Rudin CM, Holmlund J, Fleming GF, et al. Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer. Clin Cancer Res. 2001;7 (5) :1214-1220.|[2]Tolcher AW, Reyno L, Venner PM, et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2002;8 (8) :2530-2535.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2

• CAS Number:

  [177075-18-2]