ISIS 329993

• Description :

  ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP) . ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

• Product Name Alternative :

  ISIS-CRPRx

• UNSPSC :

  12352208

• Target :

  C-type Lectin-like Receptors (CTLRs)

• Type :

  Oligonucleotides

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/isis-329993.html

• Solubility :

  10 mM in H2O

• Smiles :

  [ISIS329993]

• References & Citations :

  [1]Warren MS, Hughes SG, Singleton W, Yamashita M, Genovese MC. Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis. Arthritis Res Ther. 2015;17 (1) :80. |[2]Noveck R, Stroes ES, Flaim JD, et al. Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers. J Am Heart Assoc. 2014;3 (4) :e001084.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported

• CAS Number :

  [827355-42-0]