ISIS 416858

• Description:

  ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.

• UNSPSC:

  12352100

• Target:

  Factor XI

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/isis-416858.html

• Solubility:

  10 mM in H2O

• Smiles:

  [ISIS416858]

• References & Citations:

  [1]Younis HS, Crosby J, Huh JI, et al. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood. 2012;119 (10) :2401-2408. doi:10.1182/blood-2011-10-387134

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2

• CAS Number:

  [1223657-78-0]