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(±) -AMG 487

CAT: 0804-HY-15319ASize: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15319ASize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) -AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1].
CAS Number
947536-03-0
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/racemic-amg-487.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C(C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
Molecular Formula
C32H28F3N5O4
Molecular Weight
603.59
References & Citations
[1]Johnson M, et al. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett. 2007 Jun 15;17 (12) :3339-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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