RK-0133114

• Description:

  RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775) . RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD) [1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/rk-0133114.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C (C (N[C@H] (CCC2CC2) C (NC3=CC=C (C=C3) C#N) =O) =O) NC (CC (C) (C4) C) =C1C4=O

• Molecular Formula:

  C26H30N4O3

• Molecular Weight:

  446.54

• References & Citations:

  [1]Takase S, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun. 2023 Jan 12;14 (1) :23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported