RK-0133114

• Description :

  RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775) . RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD) [1].

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/rk-0133114.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(C(N[C@H](CCC2CC2)C(NC3=CC=C(C=C3)C#N)=O)=O)NC(CC(C)(C4)C)=C1C4=O

• Molecular Formula :

  C26H30N4O3

• Molecular Weight :

  446.54

• References & Citations :

  [1]Takase S, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun. 2023 Jan 12;14 (1) :23.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported