RK-701

CAT: 0804-HY-152775-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-152775-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A[1].
CAS Number
[2648855-18-7]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rk-701.html
Purity
98.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(N[C@@H](CCC2CC2)C(NC3=CC=C(C=C3)C#N)=O)=O)NC(CC(C)(C4)C)=C1C4=O
Molecular Formula
C26H30N4O3
Molecular Weight
446.54
References & Citations
[1]Takase S, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun. 2023 Jan 12;14 (1) :23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EHMT2/G9a/KMT1C

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