RK-0080552

• Description:

  RK-0080552 (RK-552) is a NSD2 histone methyltransferase inhibitor. RK-0080552 demonstrates significant cytotoxicity against multiple myeloma (MM) cells carrying t (4;14) . RK-0080552 suppresses the IRF4 gene, reducing the level of histone H3 lysine 36 dimethylation. RK-0080552 is promising for research of hematological malignancies[1].

• Product Name Alternative:

  RK-552

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  NC1=NON=C1C(N=N2)=NC3=C2C(C4=C3C=CC=C4)=O

• Molecular Formula:

  C12H6N6O2

• Molecular Weight:

  266.22

• References & Citations:

  [1]Matsuoka S, et al. Discovery of a novel class NSD2 inhibitor for t (4; 14) -positive multiple myeloma[J]. Blood Neoplasia, 2025: 100091.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [313527-11-6]