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RK-20448

CAT: 0804-HY-118105-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118105-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259[2].
CAS Number
479501-40-1
Product Name Alternative
YH439, Ticalopride, (±)-Norcisapride; rel-Ticalopride
UNSPSC
12352005
Target
Src; Tie; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rk-20448.html
Purity
99.38
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)OC4=CC=CC=C4)=CN2[C@H]5CC[C@H](CC5)N6CCN(CC6)C
Molecular Formula
C29H34N6O
Molecular Weight
482.62
References & Citations
[1]Saito Y, et al. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013 Apr 17;5 (181) :181ra52.|[2]Almoyad MAA, et al. Hematopoietic cell kinase as a nexus for drug repurposing: implications for cancer and HIV therapy. J Biomol Struct Dyn. 2024 Mar 26:1-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Blk; Fyn; Lck; Tie2; VEGFR2/KDR/Flk-1

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