RK-1441B

CAT: 0804-HY-118043Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-118043Size:1 Each
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Description
RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance[1].
CAS Number
[132138-94-4]
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rk-1441b.html
Smiles
O=C1N2C(C(NC3=CC(O)=C(C=C13)OC)=O)CCC2O
Molecular Formula
C13H14N2O5
Molecular Weight
278.26
References & Citations
[1]New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B I. Biological Properties
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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