RK-1441B

• Description :

  RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance[1].

• UNSPSC :

  12352005

• Target :

  Antibiotic

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/rk-1441b.html

• Smiles :

  O=C1N2C(C(NC3=CC(O)=C(C=C13)OC)=O)CCC2O

• Molecular Formula :

  C13H14N2O5

• Molecular Weight :

  278.26

• References & Citations :

  [1]New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B I. Biological Properties

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [132138-94-4]