RK-1441B

• UNSPSC Description:

  RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance[1].

• Target Antigen:

  Antibiotic

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/rk-1441b.html

• Smiles:

  O=C1N2C(C(NC3=CC(O)=C(C=C13)OC)=O)CCC2O

• Molecular Weight:

  278.26

• References & Citations:

  [1]New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B I. Biological Properties

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  132138-94-4