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BRD4 Inhibitor-25

CAT: 0804-HY-151972Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151972Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD4 Inhibitor-25 is a BRD4 inhibitor with IC50s of 0.82 μM, 1.94 μM for BD1 and BD2 domains of BRD4. BRD4 Inhibitor-25 induces apoptotic and autophagy cell death in ovarian cancer cells. BRD4 Inhibitor-25 can be used in the research of cancers, cardiovascular, neuromuscular and inflammatory disorders.
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/brd4-inhibitor-25.html
Solubility
10 mM in DMSO
Smiles
[O-][N+]1=C(C(C2=CC=CC=C2)=NO1)COC(COC3=C(C=C(C=C3C)C4=NC5=C(C6=C(S5)CN(CC6)C)C(N4)=O)C)=O
Molecular Formula
C29H27N5O6S
Molecular Weight
573.62
References & Citations
[1]Zhang Y, et al. Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator. Eur J Med Chem. 2022 Nov 29;246:114970.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD4

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