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BRD4 Inhibitor-40

CAT: 0804-HY-173062Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173062Size:1 Each
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Description
BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models[1].
CAS Number
2994635-04-8
UNSPSC
12352005
Target
C-Myc; Epigenetic Reader Domain
Related Pathways
Apoptosis; Epigenetics
Field of Research
Others
Smiles
CC(N1C2=CC(NC3=NC(CC)=CC(NC4=NN(C)C5=CC=CC=C45)=N3)=CC=C2N(C([C@H]1C)=O)C)C
Molecular Formula
C27H32N8O
Molecular Weight
484.60
References & Citations
[1]Yang Y, et al., Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease. J Med Chem. 2025 Mar 13;68 (5) :5257-5274.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD4

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