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BRD4 Inhibitor-18

CAT: 0804-HY-146660Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146660Size:1 Each
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Description
BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].
CAS Number
2451219-73-9
UNSPSC
12352005
Target
Apoptosis; c-Myc; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd4-inhibitor-18.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
Molecular Formula
C26H26ClN3O3S
Molecular Weight
496.02
References & Citations
[1]Li Q, Li J, Cai Y, et al. Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors. Bioorg Med Chem. 2020;28 (15) :115601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

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