Nrf2/HO-1 activator 2
CAT:
804-HY-151431
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Nrf2/HO-1 activator 2
- CAS Number: 2883506-31-6
- UNSPSC Description: Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD)[1].
- Target Antigen: Akt; ERK; JNK; Keap1-Nrf2; Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/nrf2-ho-1-activator-2.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1C(C2=CC=C(F)C=C2F)=COC3=C1C4=C(CC(O)C(C)(C)O4)C(O)=C3
- Molecular Weight: 374.33
- References & Citations: [1]Lu Q, et, al. Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling. Eur J Med Chem. 2022 Nov 15;242:114692.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported