Nrf2 activator-2
CAT:
804-HY-145879-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nrf2 activator-2
- CAS Number: 2770448-53-6
- UNSPSC Description: Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells[1].
- Target Antigen: Keap1-Nrf2
- Type: Reference compound
- Related Pathways: NF-κB
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/nrf2-activator-2.html
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: CC1(CCC2=C3OC(C(C4=CC=CC=C4)=CC3=CC(Br)=C2O1)=O)C
- Molecular Weight: 385.25
- References & Citations: [1]Weiwei Huang, et al. Design and synthesis of Osthole-based compounds as potential Nrf2 agonists. Bioorg Med Chem Lett. 2022 Apr 1;61:128547.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported