Nrf2 activator-4
CAT:
804-HY-146086-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nrf2 activator-4
- CAS Number: 2383016-68-8
- UNSPSC Description: Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].
- Target Antigen: Keap1-Nrf2; Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/nrf2-activator-4.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(C1=CC=C(C=C1)OCC(N2CCN(CC2)C)=O)/C=C/C3=C(C=CC=C3)C(F)(F)F.Cl
- Molecular Weight: 468.90
- References & Citations: [1]Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported