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CDK8-IN-10

CAT: 0804-HY-151371Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151371Size:1 Each
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Description
CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].
CAS Number
2457317-40-5
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(N2C3=CC=NC=C3)C(OC4=NC=CC=C4C2=O)=C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
Molecular Formula
C25H15ClF3N5O3
Molecular Weight
525.87
References & Citations
[1]Martínez-González S, et, al. Pyrido[2,3-b][1,5]benzoxazepin-5 (6H) -one derivatives as CDK8 inhibitors. Eur J Med Chem. 2020 Sep 1;201:112443.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8

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