CDK8-IN-7

CDK8-IN-7

• CAS Number: 2415156-30-6
• UNSPSC Description: CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk8-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
• Molecular Weight: 428.65
• References & Citations: [1]Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported