CDK8-IN-7

CAT: 0804-HY-147717Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147717Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
CAS Number
[2415156-30-6]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-7.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
Molecular Formula
C30H40N2
Molecular Weight
428.65
References & Citations
[1]Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28 (10) :115461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8

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