Products for Research Use Only
RegisterLogin

CDK8-IN-12

CAT: 0804-HY-148561-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-148561-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent[1].
CAS Number
2613307-67-6
UNSPSC
12352005
Target
CDK; GSK-3; PKC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-12.html
Purity
99.74
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C1NCCC12CCN(C3=C(C4=CC5=CC=CC=C5O4)C=NC=C3Cl)CC2
Molecular Formula
C21H20ClN3O2
Molecular Weight
381.86
References & Citations
[1]Mingfeng Yu, et al. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 Mar 15;214:113248.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8; GSK-3α; GSK-3β; PKCθ

Related Products

CatalogName
HY-171174-01CDK8-IN-16
HY-111463-01CDK8-IN-3
HY-162600CDK8-IN-15
HY-151463-01CDK8-IN-11
HY-103492-01CDK8-IN-1
HY-147716CDK8-IN-6
HY-169541CDK8-IN-18
HY-147717CDK8-IN-7
HY-162293CDK8-IN-14
HY-176282CDK8-IN-19

Alternative Products

CatalogName
BA3859-1CDK8-IN-12
399096-01CDK8
BA3104-5CDK8-IN-13
BA3810-10CDK8-IN-1
70R-31732CDK8 antibody
GWB-728817Cdk8, Antibody
534566-01Cdk8 discontinued
501359CDK8, CT
DF2309-BPCDK8 Peptide
464161CDK8/19i

Popular Products