HDAC6/8/BRPF1-IN-1

HDAC6/8/BRPF1-IN-1

• CAS Number: 2484255-65-2
• UNSPSC Description: HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer[1].
• Target Antigen: HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac6-8-brpf1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NO)C1=CC=C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)C=C1
• Molecular Weight: 387.41
• References & Citations: [1]Ehab Ghazy, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported