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TRIM24/BRPF1-IN-2

CAT: 0804-HY-143332-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-143332-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research[1].
CAS Number
3033288-68-2
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trim24-brpf1-in-2.html
Purity
98.74
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1S(=O)(NC2=CC=C3C(CCN3C(C)=O)=C2)=O)C4CC4
Molecular Formula
C20H22N2O4S
Molecular Weight
386.46
References & Citations
[1]Xiang Q, et al. Discovery, optimization and evaluation of 1- (indolin-1-yl) ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. Eur J Med Chem. 2022 Jun 5;236:114311.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRPF1

Chemical Information

Trim24/brpf1-IN-2
CAS Number3033288-68-2
PubChem CID164946756
IUPAC NameN-(1-acetyl-2,3-dihydroindol-5-yl)-5-cyclopropyl-2-methoxybenzenesulfonamide
Molecular FormulaC20H22N2O4S
Molecular Weight386.5
XLogP2.7
Topological Polar Surface Area84.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity657
SMILES
CC(=O)N1CCC2=C1C=CC(=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4CC4)OC
InChI
InChI=1S/C20H22N2O4S/c1-13(23)22-10-9-16-11-17(6-7-18(16)22)21-27(24,25)20-12-15(14-3-4-14)5-8-19(20)26-2/h5-8,11-12,14,21H,3-4,9-10H2,1-2H3
InChIKey
GUDHFUSYMUTOKE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trim24/brpf1-IN-2
CAS: 3033288-68-2
CID: 164946756
Formula: C20H22N2O4S
MW: 386.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.5
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass386.13002836
Monoisotopic Mass386.13002836
Topological Polar Surface Area84.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity657
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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