HDAC8/BRPF1-IN-1

HDAC8/BRPF1-IN-1

• CAS Number: 2484255-85-6
• UNSPSC Description: HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1].
• Target Antigen: Epigenetic Reader Domain; HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac8-brpf1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1
• Molecular Weight: 417.44
• References & Citations: [1]Ghazy E, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported