BChE/HDAC6-IN-1

• UNSPSC Description:

  BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research[1].

• Target Antigen:

  Cholinesterase (ChE); HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bche-hdac6-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(NC(CCCCCCC(NO)=O)=O)=CC=C3)=O)=CC=C2

• Molecular Weight:

  601.74

• References & Citations:

  [1]Lei Wang, ET AL. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2925457-27-6