mTOR/HDAC6-IN-1

mTOR/HDAC6-IN-1

• CAS Number: 2986747-52-6
• UNSPSC Description: mTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively). mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC)[1].
• Target Antigen: Apoptosis; Autophagy; HDAC; mTOR
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mtor-hdac6-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CN1CCN(CC1)C2=NC(C3=CC=C(C=C3)C(NO)=O)=NC4=CC(Cl)=CC=C42
• Molecular Weight: 397.86
• References & Citations: [1]Yao D, et al. Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells. Bioorg Med Chem Lett. 2021;47:128204.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported