CDK8-IN-9

CAT: 0804-HY-151255Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151255Size:1 Each
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Description
CDK8-IN-9 (compound 22) is a potent type II CDK8 inhibitor with an IC50 value of 48.6 nM. CDK8-IN-9 can inhibit tumor growth and is used in colorectal cancer studies[1].
CAS Number
[2850253-95-9]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C)C(C(F)(F)F)=C1)CCC2=CC=CC(C3=CN=C(NC=C4)C4=C3)=C2
Molecular Formula
C24H20F3N3O
Molecular Weight
423.43
References & Citations
[1]Xing Xing Zhang, et al. Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer. J. Med. Chem.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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