UNC-CA359

CAT: 0013-GTR19187487-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19187487-01Size:25 mg

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Description

UNC-CA359 is a potent and selective EGFR inhibitor with an IC50 of 18 nM. It exhibits robust anti-tumor activity in vitro and has shown promising efficacy in preclinical chordoma models, highlighting its potential for targeted cancer research.

CAS Number

2676156-05-9

Field of Research

Cardiovascular Research, Signal Transduction

Smiles

N (C=1C2=C (C=C (OC) C (OC) =C2) N=CN1) C3=CC (C#C) =C (Cl) C=C3

Molecular Formula

C18H14ClN3O2

Molecular Weight

339.78

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Unc-CA359

CAS Number	2676156-05-9
PubChem CID	164886643
IUPAC Name	N-(4-chloro-3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular Formula	C18H14ClN3O2
Molecular Weight	339.8
XLogP	4.2
Topological Polar Surface Area	56.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	24
Formal Charge	0
Complexity	468

SMILES

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)Cl)C#C)OC

InChI

InChI=1S/C18H14ClN3O2/c1-4-11-7-12(5-6-14(11)19)22-18-13-8-16(23-2)17(24-3)9-15(13)20-10-21-18/h1,5-10H,2-3H3,(H,20,21,22)

InChIKey

KQFANGBOVPXOEP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2676156-05-9

CID: 164886643

Formula: C18H14ClN3O2

MW: 339.8

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	339.8
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	339.0774544
Monoisotopic Mass	339.0774544
Topological Polar Surface Area	56.3 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	468
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-150782	UNC-CA359
MBS7032903-01	Recombinant Innexin unc-9 (unc-9)
MBS7032902-01	Recombinant Innexin unc-7 (unc-7)
MBS7032897-01	Recombinant Protein unc-50 (unc-50)
MBS7032891-01	Recombinant Protein unc-1 (unc-1)
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B4941-5	UNC 3230
A4504-50	UNC 0646
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A4503-10	UNC 0224

UNC-CA359

Chemical Information

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