EGFR-IN-71

CAT: 0804-HY-150781Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-150781Size:1 Each
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Description
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1]. EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2676155-98-7]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-71.html
Solubility
10 mM in DMSO
Smiles
IC1=CC2=NC=NC(NC3=CC=C(Cl)C(C#C)=C3)=C2C=C1
Molecular Formula
C16H9ClIN3
Molecular Weight
405.62
References & Citations
[1]Bieberich AA, et al. Optimization of the 4-anilinoquin (az) oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27;12 (1) :12820.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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