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NLRP3-IN-71

CAT: 0804-HY-173046Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173046Size:1 Each
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Description
NLRP3-IN-71 (Compound 19) is a BBB-permeable, orally active and selective NLRP3 inhibitor that can inhibit IL-1β secretion. NLRP3-IN-71 can be used for the research of neurodegenerative diseases[1].
CAS Number
3026419-44-0
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
OC(C=C(C=C1)C(F)(F)F)=C1C2=NN=C(C3=NC=CN32)N[C@H]4CN(CCC4)C
Molecular Formula
C18H19F3N6O
Molecular Weight
392.38
References & Citations
[1]Mammoliti O, et al. Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity. J Med Chem. 2025 Feb 27;68 (4) :4848-4887.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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