KPC-2-IN-1

CAT: 0804-HY-150766Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-150766Size:1 Each
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Description
KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2].
CAS Number
[2232877-85-7]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kpc-2-in-1.html
Solubility
10 mM in DMSO
Smiles
OB(C1=CC=CC(CN2N=NC(C3=CSC=C3)=C2)=C1)O
Molecular Formula
C13H12BN3O2S
Molecular Weight
285.13
References & Citations
[1]Zhou J, et al. Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. Eur J Med Chem. 2022 Jun 28;240:114571.|[2]Zhou J, et al. Boronic acid inhibitors of the class A β-lactamase KPC-2. Bioorg Med Chem. 2018 Jul 15;26 (11) :2921-2927.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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