KPC-IN-1

• Description :

  KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC50=8.3 nM) . KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  FC1=CC2=CC=CC(B(O)O)=C2N=C1C(O)=O

• Molecular Formula :

  C10H7BFNO4

• Molecular Weight :

  234.98

• References & Citations :

  [1]Ma Z, et al. 2-Carboxyquinoline Boronic Acids as Highly Potent KPC Inhibitors. ChemMedChem. 2024 Dec 27:e202400901.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported