KPC-2-IN-3

• Description :

  KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533 μM and Kiof 0.194 μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem (HY-13678) . KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model[1].

• UNSPSC :

  12352128

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  FC1=CC=C(C(B(O)O)=C1)/C=C/P(O)(O)=O

• Molecular Formula :

  C8H9BFO5P

• Molecular Weight :

  245.94

• References & Citations :

  [1]Singh M, et al. Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to β-Lactam Antibiotics. J Med Chem. 2025 Jul 10;68 (13) :13421-13435.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported