KCL-440

KCL-440

• CAS Number: 651029-09-3
• UNSPSC Description: KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1[1][2].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: COVID-19-anti-virus
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/kcl-440.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31
• Molecular Weight: 294.35
• References & Citations: [1]Yasuhiko Ikeda, et al. Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. Brain Res. 2005 Oct 26;1060(1-2):73-80.|[2]Tatsushi Kamiya, et al. The neuroprotective effects of a newly synthesized poly (ADP-ribose) polymerase (PARP) inhibitor (KCL-440) on neuronal cell death following transient focal ischemia in rat. Journal of Cerebral Blood Flow & Metabolism. 2005.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported