PYZD-4409

• Description :

  PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay) . PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H319, H335

• Target :

  E1/E2/E3 Enzyme

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PYZD-4409.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 35 mg/mL

• Smiles :

  FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl

• Molecular Formula :

  C14H7ClFN3O5

• Molecular Weight :

  351.67

• Precautions :

  H301, H315, H319, H335

• References & Citations :

  [1]Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115 (11) :2251-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [423148-78-1]