PYZD-4409

• Description:

  PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay) . PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H335

• Target:

  E1/E2/E3 Enzyme

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PYZD-4409.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 35 mg/mL

• Smiles:

  FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl

• Molecular Formula:

  C14H7ClFN3O5

• Molecular Weight:

  351.67

• Precautions:

  H301, H315, H319, H335

• References & Citations:

  [1]Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115 (11) :2251-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [423148-78-1]