RegisterLogin

JNc-440

CAT: 0804-HY-120514Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120514Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1].
CAS Number
[1119503-63-7]
UNSPSC
12352005
Target
Potassium Channel; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/jnc-440.html
Purity
98.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NCCCNC(C(C3=CC=CC=C3)C4=CC=CC=C4)=O
Molecular Formula
C26H24N4O3
Molecular Weight
440.50
References & Citations
[1]He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9 (11) :1491-1503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4

Related Products

CatalogName
HY-15050KCL-440
HY-W953004CRBN ligand-440
HY-Y1219CSilica gel, high-purity grade, 220-440 mesh
HY-U00217AZD 4407
HY-13297-01PYZD-4409
HY-12909-01MK-4409
HY-P76972-01Gag-Pol polyprotein, HIV (440a.a, His)
HY-P990163Anti-Mouse Siglec-H Antibody (440c)

Alternative Products

CatalogName
T62543-01JNc-440
MBS3601895-01GBT-440
451112-01GBT 440
T34413-01KCL-440
T35265YM-440
TRC-G268016-100MGGBT 440-D7
#92124CF®440 Maleimide
#96064CF®440 Hydrazide
#96070CF®440 BCN
44900-AATIFluor® 440 Styramide

Popular Products