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JNc-440

CAT: 0804-HY-120514Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120514Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1].
CAS Number
1119503-63-7
UNSPSC
12352005
Target
Potassium Channel; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/jnc-440.html
Purity
98.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NCCCNC(C(C3=CC=CC=C3)C4=CC=CC=C4)=O
Molecular Formula
C26H24N4O3
Molecular Weight
440.50
References & Citations
[1]He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9 (11) :1491-1503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4

Chemical Information

N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS Number1119503-63-7
PubChem CID135658581
IUPAC NameN-[3-[(2,2-diphenylacetyl)amino]propyl]-4-oxo-3H-quinazoline-2-carboxamide
Molecular FormulaC26H24N4O3
Molecular Weight440.5
XLogP3.4
Topological Polar Surface Area99.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity707
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NCCCNC(=O)C3=NC4=CC=CC=C4C(=O)N3
InChI
InChI=1S/C26H24N4O3/c31-24-20-14-7-8-15-21(20)29-23(30-24)26(33)28-17-9-16-27-25(32)22(18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-8,10-15,22H,9,16-17H2,(H,27,32)(H,28,33)(H,29,30,31)
InChIKey
VMRVWMQQRPXUQU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS: 1119503-63-7
CID: 135658581
Formula: C26H24N4O3
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass440.18484064
Monoisotopic Mass440.18484064
Topological Polar Surface Area99.7 Ų
Heavy Atom Count33
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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