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KCL-HO-1i

CAT: 0013-GTR19273111-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273111-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KCL-HO-1i is an orally active heme oxygenase-1 (HO-1) inhibitor with an IC50 of 123 nM for rat HO-1 and 128 nM for human HO-1. It targets immune-suppressive LYVE-1+ perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME) and reduces PvTAM-mediated immune evasion. In MMTV-PyMT mice with spontaneous breast cancer or C57Bl/6 mice with subcutaneous MN-MCA1 sarcoma, KCL-HO-1i demonstrates synergistic anti-tumor effects when combined with chemotherapy. It is applicable for cancer research.
Storage Conditions
-20°C
Notes
For research use only.

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