GluN2A Allosteric modulator 1

• Description :

  GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penetrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC50 values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases[1].

• UNSPSC :

  12352005

• Target :

  IGluR

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=NC=C(OCC(F)(C2=CC(Cl)=CC=C2)F)N=C1)NC3(C4=NC=CN=C4)CC3

• Molecular Formula :

  C20H16ClF2N5O2

• Molecular Weight :

  431.82

• References & Citations :

  [1]Bischoff FP, et al. Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration. J Med Chem. 2025 Feb 27;68 (4) :4672-4693.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NMDA Receptor