GluN2A Allosteric modulator 1

• Description:

  GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penetrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC50 values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases[1].

• UNSPSC:

  12352005

• Target:

  IGluR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  O=C (C1=NC=C (OCC (F) (C2=CC (Cl) =CC=C2) F) N=C1) NC3 (C4=NC=CN=C4) CC3

• Molecular Formula:

  C20H16ClF2N5O2

• Molecular Weight:

  431.82

• References & Citations:

  [1]Bischoff FP, et al. Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration. J Med Chem. 2025 Feb 27;68 (4) :4672-4693.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NMDA Receptor