iNOS/COX-2-IN-3

iNOS/COX-2-IN-3

• UNSPSC Description: iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC50=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively[1].
• Target Antigen: COX; NO Synthase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/inos-cox-2-in-3.html
• Smiles: O=C(C1=NN(C2=CC=C(F)C=C2)C(CCl)=N1)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(C3=NN(C4=CC=C(F)C=C4)C(CCl)=N3)=O
• Molecular Weight: 1065.93
• References & Citations: [1]Li SM, et al. Synthesis, physicochemical characterization, and investigation of anti-inflammatory activity of water-soluble PEGylated 1,2,4-Triazoles. Bioorg Chem. 2024 Jun;147:107312.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported