ERRγ inverse agonist 1

• Description:

  ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC50 of 40 nM[1].

• UNSPSC:

  12352005

• Target:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ERR_gamma__Inverse_Agonist_1.html

• Solubility:

  10 mM in H2O

• Smiles:

  OC1=CC=CC (/C (C2=CC=C (N3CCN (C (C) C) CC3) C=C2) =C (C4=CC=CC=C4) \CCCO) =C1.[H]Cl.[H]Cl

• Molecular Formula:

  C30H38Cl2N2O2

• Molecular Weight:

  529.54

• References & Citations:

  [1]Kim J, et al. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem. 2019 Feb 28;62 (4) :1837-1858.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ERRβ; ERRγ; ERα

• CAS Number:

  2316832-86-5