ERRγ inverse agonist 1

• Description :

  ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC50 of 40 nM[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ERR_gamma__Inverse_Agonist_1.html

• Solubility :

  10 mM in H2O

• Smiles :

  OC1=CC=CC(/C(C2=CC=C(N3CCN(C(C)C)CC3)C=C2)=C(C4=CC=CC=C4)\CCCO)=C1.[H]Cl.[H]Cl

• Molecular Formula :

  C30H38Cl2N2O2

• Molecular Weight :

  529.54

• References & Citations :

  [1]Kim J, et al. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem. 2019 Feb 28;62 (4) :1837-1858.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERRβ; ERRγ; ERα

• CAS Number :

  [2316832-86-5]