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TGR5 agonist 1

CAT: 0804-HY-149807Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149807Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGR5 agonist 1 (compound 18) is a potent TGR5 agonist with an EC50 value of 0.31 µM[1].
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12C[C@@H](C)[C@]3([H])[C@](CC[C@@]3([H])[C@]1([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@@]42C)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O
Molecular Formula
C28H48NNaO6S
Molecular Weight
549.74
References & Citations
[1]Luxenburger A, et al. The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists. Eur J Med Chem. 2023 Mar 15;250:115143.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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