TGR5 Receptor Agonist 4

• UNSPSC Description:

  TGR5 Receptor Agonist 4 is an agonist of Bile Acid Receptor (TGR5), with EC50 for hTGR5 and mTGR5 of 2 nM and 3 nM, respectively. TGR5 Receptor Agonist 4 plays important roles in hypoglycemic and weight loss[1].

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tgr5-receptor-agonist-4.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC(C=CC=C1)=C1COC(C([C@H](C2=CN=C(Cl)C=C2)C3)=C(C)N(C[C@H]4CCCO4)C3=O)=O

• Molecular Weight:

  470.95

• References & Citations:

  [1]Sylvain Picon, et al. Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5. J Med Chem. 2023 Sep 14;66(17):11732-11760.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1872436-42-4